Mushonga wechiAkatinol Memantine inorapa mushonga wepiritsi, iyo inoshandiswa mukudengenyeka kwepfungwa - kuderera kwehutano hwepfungwa nekupererwa kwepfungwa, kufunga, kukanganisa, kurasikirwa kweunyanzvi hwakawana uye zvimwe zvisiri izvo.
Muzviitiko zvakawanda, chirwere ichi chinokura zvishoma nezvishoma uye chakasiyana kune vakwegura, asi dzimwe nguva chinoitika kune vechidiki nevana pasi pekuita kwezvinhu zvinokonzera rufu rwemasero mu cerebral cortex. Izvi zvinogona kuitika semugumisiro wekukuvara kwekriocerebral, kudhakwa, zvirwere, zvirwere zvevascular, nezvimwewo.
Acatinol Memantine chirwere chinoshandiswa pamutemo chinokonzerwa muGermany nekambani yekambani yemishonga Merz, iyo inogadziridza ichi chemishonga yekurapa kwekuita kwemagariro evanhu. Zvisinei, nhasi kune zvakawanda zvakafananidzwa (generic) zveAkatin Memantine, yakagadzirwa nevamwe vanogadzira, kusanganisira mhuri. Heino urongwa hwemishonga iyi, asi kutanga tichatarisa kuti izvi zvinodhaka zvinoshanda sei mumuviri.
Pharmacological action yeAcathinol Memantine
Iyo inonyanya kushandiswa chikamu chechirwere ichi Akatinol Memantine, pamwe chete nemagariro ayo, ndiyo memantine hydrochloride compound. Ichi chinhu, chakakonzerwa kubva mumakumbo uye chinopinda muropa, ine zvinotevera:
- kukurudzira kwe glutamatergic system
- mutemo wekutakura kweioni muyeuroni;
- Kuvandudzwa kwehutano hwekushaya simba uye kufarira chizvarwa;
- normalization membrane potential;
- kuderera mukudya kwekonikioni ye ionised in neurons, nezvimwewo.
Somugumisiro, zvinotevera kurapwa kunoitwa:
- kuwedzera muhutano hwehuropi;
- kuwedzera kwemaitiro epfungwa;
- kuvandudza chiyeuchidzo, kukwanisa kuisa pfungwa;
- kuderedza kuneta uye zviratidzo zvekuora mwoyo;
- kupera kwekutaura kwekutaura;
- basa rakawedzerwa mumuviri;
- kuderedza kuparadzaniswa kwemakumbo emasumbu.
Kutora mishonga inobva pamagumisiro inokubvumira kuti usiye kufambira mberi kwezvirwere zvepfungwa, kuchengetedza varwere kukwanisa kuzviitira.
List of analogues of Acatinol Memantine:
- Alzheim (Argentina);
- Memantine-TL (Russia);
- Memanine (Russia);
- Mémicar (Russia);
- Chirangaridzo (Russia);
- Noogeron (Croatia);
- Abixa (Denmark).
Kushandiswa kweAcatinol Memantine uye yakafanana nayo
Matafura Akatinol Memantine, pamwe nekuisa mishonga yemishonga, inokurudzirwa kushandisa panguva yekudya, yakashambidzwa pasi nemvura (pasina chido chekucheka). Muyero wechirwere ndewemunhu mumwe nomumwe murwere. Nhamba yekutanga, sekutonga, ndeye 5 mg pazuva. Mushure mechinguva, muyero unowedzera (kazhinji kazhinji kusvika 30 mg pazuva).
Iko kunofanirwa kutakurwa mupfungwa kuti madhiragi anobva pamuminini anogona kunyoreswa chete nechiremba uye anofanira kutorwa pasi pekutarisirwa kweutano. Mukuwedzera, pakurapa kwekuora mwoyo, zviyero zvehutano zvemuviri zvinofanira kushandiswa, zvinosanganisira kudya kwakakwana, zvakakodzera mumuviri uye mupfungwa, nezvimwewo.
Contraindications kushandiswa kwemifananidzo yeAcatinol Memantine
Acatinol Memantine uye mifananidzo yayo inokurudzirwa kuti ishandiswe nekuchenjerera kurapwa pamberi pezvinotevera zvinoratidzira:
- heart failure;
- thyrotoxicosis ;
- kuora mwoyo;
- myocardial infarction;
- kunetseka.
Mune zviitiko izvi, mishonga inogona kupiwa inoshandiswa kuti ishandiswe mumadhora maduku.
Uyezve, mishonga inobva pamagumisiro haisati yanyorerwa:
- mimba uye lactation;
- akaratidza kuputsa kweiyo mafungiro;
- kunyanya kusawirirana kune zvikamu zvechirwere.