Bilirubin ikemikari yakawanda, chimwe chezvikamu zvikuru zveB bile zvakakonzerwa nemasero eropa uye kugoverana mukugadzira chirwere. Icho chinotyisa che pigment chinoumbwa apo kuparadzwa kana kuora erythrocytes zvikamu zvemuropa, uye izvi zvinowanikwa mu spleen. Uyezve, bilirubin inopinda mukati memasero eropa uye inoshanduka kuva imwe, iyo inogadzikana mumvura.
Zvidimbu zvebilirubin
Bilirubin mumuviri womunhu uye, kunyanya muropa remvura, inomiririrwa nemhando mbiri dzezvikamu:
- Chikamu chisinganzwisisiki (isina) , icho chinonzi bile pigment, chisingasviki mumvura uye kuva nekwanisi kupfuura nepakati memakumbo esero uye kuvhiringidza basa ravo.
- Chikamu chakasununguka (chakasungwa) , chinowanikwa nokubatanidza bhalirubin yakachena mu hepatocytes uye ine mvura inogadzikana mumvura.
Nhamba yemafungiro asinganzwisisiki uye anorondedzera bilirubin muropa ropa rose (rose) bilirubin, kusarudzwa kwezvinoitwa panguva yekudzidza kwechimirochemical ye bloodous venous. Ngationgororei, chii chinowanzoitwa kana kuti chiyero chebhizinubin muropa kune vakadzi uye nezvekupi kuongorora kwechiratidzo chinopiwa kunogona kutaura.
Muitiro wekubata bilirubin muropa
Kuti uone huwandu hwebilirubin huri mumutambo wekufamba, ropa rinotorwa kubva mumvura yakasviba panguva yamangwanani pane isina chinhu mudumbu. Nzira dzakasiyana-siyana dzinoshandiswa pakuongorora. Inofanira kuonekwa kuti zvinhu zvakasiyana-siyana zvinokonzera kunaka kwekuongorora. Nokudaro, zvingangodaro zvingave zvakanyanyisa kufungidzirwa kana mushure mekudzidza murwere akatora steroid maigadziro, erythromycin, phenobarbital, inodya zvokudya nepamusoro wezvakanyorwa zve carotenoids (karoti, apricots). Uwandu hwehutsika hunogona kugadziriswa nemhosva yevashandi vehutano avo vakabvumira kusara kwenguva refu kwemashoko vari pasi pechidzidzo muchiedza, zvichidaro zvichikonzera kusvibiswa kweserum.
Chimiro chevakadzi ndiwo maonero ehuwandu hwebilirubin, kuchinja mukati me 3.4 - 17.1 μmol / l (iyo 80% inowira pane chikamu chisina kujeka). Kune varume, chikamu chepamusoro chezvinhu zvakanakira tsika dzechiratidzo ichi zvishoma. Icho chikonzero chinokonzerwa nekuti nhamba shomanana eerythrocytes inobudiswa mumuviri wevakadzi. Inofanirawo kuonekwa kuti munguva yekubata muviri, kunyanya mumatatu ekupedzisira, pangangodaro kune zvishoma zvishoma zvechimiro chechiratidzo chiri mubvunzo, sechikonzero chekutyora kwebi kubva pachiropa. Zvisinei, mushure mekusununguka, kukosha kunowanzodiwa.
Kuongorora kwekukosha kwechirwere che bilirubin
Kuwedzera kwebilirubin muropa rinopa ruzivo rwakakosha pamusoro pehutano hwemagetsi ematabolism mumuviri, masimba anoshanda ezvikamu anobatanidzwa mukushandurana uku, anobvumira vanachiremba vemhando dzakasiyana-siyana kuti vaongorore uye vaongorore kushanda kwehutano hwezvirwere zvakawanda. Kazhinji kacho, kuongororwa uku kwakakurudzirwa kwekufungidzirwa kwechiropa chirwere, hemolytic anemia. Inofanira kunzwisiswa kuti chiratidzo chehuwandu hwebilirubin hachibvumiri kuti tinyatsonzwisisa chikonzero chekuwedzera kwayo. Nokudaro, chidzidzo chinofanirwa kunge chichigadziriswa nekudzidza kwezvikamu zvebilirubin muropa.
Kana panguva yekuongororwa ichitarirwa kuti kuwedzera kwebilirubin yakazara kunokonzerwa nehuwandu hwehuwandu hushoma, izvi zvinogona kuratidza:
- hemolytic anemia ;
- malariya;
- Chirwere cheGilbert;
- kriegler-Nayar syndrome, nezvimwewo.
Apo iyo yose bilirubin inowedzerwa nekuda kwechikamu chepakati, munhu anogona kunyunyuta nezve:
- Dabin-Johnson syndrome;
- hepatitis;
- cirrhosis;
- cholelitiasis, nezvimwe.
Kupfuurira mitemo yezvikamu zviviri zvinogona kutaura pamusoro pematambudziko akadaro se:
- chiropa cheropa;
- alveococcosis chechiropa;
- chirwere chetachipatara, nevamwe.
Kuderedza bhalirubini yakakwana muropa inochengetwa mushure mokurasikirwa kweropa kukuru kwomuviri, zvichirwisana nemamiriro ezvinhu evanhu vakawanda dystrophy.