Chirwere cheCreutzfeldt-Jakob chakatsanangurwa nemasayendisiti maviri eGermany, ane mazita avo ainzi chirwere, pakutanga kwekutanga kwezana remakore rechi20. Kunyange zvazvo kubva panguva iyoyo yapfuura makore anopfuura zana, chirwere chechirwere ichi hachina kumbowanikwa. Masayendisiti akakwanisa kuziva kuti chii chinokonzerwa nechirwere ichi - hostile prion, asi haikwanise kudzidza kudzidza.
Creutzfeldt-Jakob chirwere - chii ichocho?
Creutzfeldt-Jakob chirwere cheponi chinokura semugumisiro wegenji inotenderera inokonzerwa nehupenyu hwomunhu hunovenga, protein prion. Zvinotendwa kuti zvinobva puroteni iyi zvipfuwo, asi tsvakurudzo itsva inofungidzira kuti chirwere ichi chinowanzoitika uye pasina chikonzero chekunze. Vatsvakurudzi vanodavira kuti chirwere cheKHH (chirwere chinotyisa chemhou) chiri kufambira mberi, uye mamiriro evanhu matsva ezvirwere anoonekwa. Mumakore ekuma1990, zviitiko zve subspecies zvechirwere ichi zvakanyorwa, iyo yainzi mhuka yakaipa yemhou.
Pakupedzisira, chirwere chacho chakabata vanhu vakwegura kune makore makumi matanhatu, asi ikozvino pane zviitiko zvekukuvadza kune vechidiki. Prion chirwere chinokanganisa uropi, semugumisiro wekugadzirisa matanho uye unhu hunotanga kutambura mumunhu. Kubudirira kwechironda kunounza kuwedzera kwezviratidzo, kushushikana kwekutaura, kukanganisa uye paresis yemakumbo. Nhamba yepamusoro yechirwere ichi ndechekufa uye kufa. Mushure moutachiona, munhu haaraperi makore maviri. Ivhareji yekutarisira hupenyu kwekutanga kwekuparara ndeye mwedzi 8.
Creutzfeldt-Jakob chirwere - causative agent
Utachiona hwemhou dzinokonzerwa nemhou hunokonzerwa ne mutant prion protein. Zvipfeko zviripo mumuviri wemunhu, asi zvine chimiro chakasiyana. Iyo proteine inonyangadza inouya kubva kunze haifaniri mumuviri womunhu, asi inouya kubva muropa kusvika kune uropi. Ikoko anotanga kushamwaridzana nevanhu, izvo zvinoita kuti pave nekushandura mune zvavakaita. Icho chinotapukira chinokonzera mapepa pamusoro peeurons, mushure mezvo neuron inoparara.
Creutzfeldt-Jakob chirwere - nzira yeutachiona
Masayendisiti anosiyanisa nzira dzakadaro dzehutachiona hwechirwere cheCreutzfeldt-Jakob:
- kudyarwa kwehutachiona hwehutachiona hutachiwana hwehutachiona hwepabonde;
- kuwedzerwa ropa rakasvibiswa;
- kutapurirwa kwehutachiona kuburikidza nemhando dzisina kuchena dzakasvibiswa zvekuvhiya;
- kudya zvisina kunaka nyama yakatapukirwa yemhou, makwai, mbudzi.
Denda reCreutzfeldt-Jakob - zvinokonzera
Izvozvo zvinokonzerwa nehutano hweCreutzfeldt-Jakob chirwere hachisi kunyatsogadziriswa. Kunyange zvazvo shanduro ye ingress yemumwe mutorwa prion kubva kunze (kazhinji kubva kumhuka) inowanzogamuchirwa, pane dzimwe dzidziso. Imwe yezvinyorwa ndeyekufungidzira kuti munhu prion, akachinjwa nekuda kwechimwe chikonzero, anotanga kushandura mapaundi emunharaunda, izvo zvinotungamirira pakukundwa kwezvivako zvakasiyana zveuropi.
Mutagenic prions nechirwere cheCreutzfeldt-Jakob chinotanga kushanda pakurwisana nemhuka. Dzinodzivirira sero kuti isapedza basa rayo, ichivhara maitiro anowanikwa mairi. Somugumisiro wemabhononi, sero rinouraya. Pasi pemasere akafa, zvirwere zvinoputika zvinowedzera, umo maune enzymes ane simba anobatanidzwa. Zvinhu izvi zvinopesana nebasa remasero ane utano, nokudaro kuwedzera kukanganisa kune zvivako zveuropi.
Creutzfeldt-Jakob chirwere - zviratidzo
Mhando dzechirwere mumakumbo mune vanhu vane zviratidzo zvinomiririra pane nzvimbo yechigunwe pachigamba chekutanga chinoratidza zviratidzo zvakadaro:
- kudodzwa, kutsamwa;
- musoro, chizoro ;
- matambudziko nehope;
- kuora kwemaonero;
- kusava nehanya, kusava nekutora;
- kukanganwa kwepfungwa ;
- kuderedza libido;
- episodic euphoria kana kutya;
- delirium kana kurovedza;
- matambudziko nekutaura;
- paresis yemakumbo, unsteadiness paanenge achifamba.
Muchikamu chechipiri, chirwere chemhou chinotyisa, zviratidzo zvekuwedzera kwacho, chinoratidzwa nezviratidzo zvakadaro:
- kuora mwoyo kwakagumburwa ;
- kuparara;
- kurasikirwa kwemasumbu kudzora, kudengenyeka;
- dementia;
- kutaura kwakanyanya kusaparara;
- zvinetso zvepfungwa.
Icho chigumo chinotarisana nezviratidzo zvinotevera:
- mamiriro ehupfeko;
- kurasikirwa kwekutonga kwe nhengo dzepelvic;
- kupera simba;
- complete paralysis;
- coma.
Kreutzfeldt-Jakob chirwere - kuongororwa
Kujekesa kuongororwa kunoda kliniki yakakwana yemifananidzo, yakasimbiswa nedhigiriji. Muchiitiko ichi, chiremba, paanounganidza annesnesis, anoona munzvimbo iyo murwere anorarama, pasinei nevekukurukurirana nemombe. Zvakakosha kuziva zviratidzo izvo murwere akazvitaura. Kunyanya kukoshesa kunobhadharwa kune matambudziko ane maonero, pfungwa uye magetsi.
Dhiyabhorosi data inosanganisira migumisiro yeongororo dzakadaro:
- EEG (electroencephalogram) - ichaderedzwa basa ne periodic kana pseudoperiodic acute waves.
- PET yeuropi.
- Creutzfeldt-Jakob chirwere, MRI umo T2-mode inoshandiswa, inowanikwa mukuongororwa neanonzi "uchikiti chiratidzo" - nzvimbo dzine zviratidzo zvakakwirira.
- Lumbar kuvhara kwekudzidza kweperebrospinal fluid.
- Stereotoxic biopsy yeuropi, iyo inobvumira kuona chirwere chinotapukira.
Creutzfeldt-Jakob chirwere - kurapwa
Sezvo pasina chikonzero chaiicho chechirwere, hapana mushonga wakawanikwa pairi. Kuvharirwa kwemhou nevarume hazvina kuuya nemigumisiro yaidiwa. Usaita zvinhu zvinotyisa uye zvinodhaka. Vatsvakurudzi vakakwanisa kunzwisisa nzira yekuwedzera nayo hupenyu hwemasero ane utachiona, asi iyi inongova chiito chiduku mukutsvaga mishonga inoshanda. Panguva ino, chirwere chemombe chakashata mumunhu chinongoratidzwa zviratidzo chete. Murwere anorayirwa anticonvulsant uye antiepileptic zvinodhaka.