Cytotoxic madhiragi iboka remishonga iro chiito chayo chinangwa chekudzivisa kana kudzivisa nzira dzekudzivirira masero echitsauko uye kukura kwehutachiona hunogadzirisa.
Inguva ipi cytostatics inorayirwa?
Nzvimbo huru yekushandiswa kwemishonga iri mubvunzo ndeyekurapa kwezviremara zvinouraya izvo zvinoratidzwa nechisimba chisina kudzora seroja (kanha, leukemia , lymphomas, nezvimwewo).
Kusvikira zvishoma, migumisiro yemishonga iri muboka iri inotarisana nemasero mashoma ekuparadzanisa masero emapfupa emapfupa, ganda, mucous membrane, epithelium yechipfuva chemuviri. Izvi zvinobvumira kushandiswa kwe cytostatics zvakare mune zvirwere zvinodzivirira (rheumatoid arthritis, scleroderma, lupus nephritis, Chirwere cheGoodpasture, systemic lupus erythematosus, nezvimwewo).
Sechikamu chemishonga yakaoma, cytotoxic zvinogona kutarisirwa mumuromo semapiritsi, capsules, kana sejojo (intravenous, intra-arterial, intraluminal, intravitreal). Nguva yenguva yekurapa inoratidzirwa nekuoma kwechirwere, kubudirira uye kushivirira kwechirwere.
Rwendo rwe cytotoxic zvinodhaka
Cytostatics inorondedzerwa kuitira chinangwa chekuraira, uye ichi chikamu chinogumira, nokuti mishonga yakawanda yeboka rimwechete ine nzira yakasiyana yekuita uye inobudirira kurwisana zvakasiyana-siyana zvakasiyana-siyana zvezviremara zvinotyisa. Heino mutsara mukuru wemazita e-cytotoxic madhiragi:
1. Mishonga inodhaka:
- alkylsulfonates (Busulfan, Treosulfan);
- ethylenimines (Thiotepa);
- zvinyorwa zve nitrosoureas (Nimustine, Lomustine, Carmustine, Mystophoran, Streptozotocin);
- chloroethylamines (Chlorambucil, Ifosfamide, Bendamustine, Cyclophosphamide, Melphalan, Trophosphamide).
2. Zvinyorwa zvezvirimwa zvakabva:
- podophyllotoxins (Teniposide, Etoposide);
- taxanes (docetaxel, paclitaxel);
- vinaalkaloids (Vindesin, Vincristine, Vinblastine, Vinorelbine).
3. Antimetabolites:
- vanopikisa folic acid (Ralitrexed, Methotrexate);
- Purine antagonists (Cladribine, Fludarabine, Pentostatin, Thioguanine);
- vanopikisa ve pyrimidine (cytarabine, capecitabine, gemcitabine, fluorouracil).
4. Mishonga inorwisa mabhakitiriya ane basa rinopikisa:
- anthracyclines (Doxorubicin, Daunorubicin, Epirubicin, Idarubicin, Mitoxantrone);
- mamwe antitumoral antibiotics (mitomycin, bleomycin, plikamycin, dactinomycin).
5. Dzimwe cytostatics:
- zvinyorwa zve camptothecin (Irinotecan, Topotecan);
- zvinyorwa zve platinum (Cisplatin, Carboplatin, Oxaliplatin);
- vamwe (Temozolomide, Altrethamine, Estramustine, Amsacrine, L-asparaginase, Dacarbazine, Hydroxycarbamide, Procarbazine).
6. Monoclonal antibodies (Trastuzumab, Ederkolomab, Rituximab).
7. Mahomoni anonzi Cytostatic:
- antiandrogens (cyproterone acetate, bicalutamide, flutamide);
- progestins (Medroxyprogesterone acetate, Megestrol acetate);
- estrogens (Polyestradiol, Phosphastrol);
- antiestrogens (Toremifene, Tamoxifen, Droloxifene);
- aromatase inhibitors (Anastrozol, Formestan, Exemestane).
- LH-RH agonist (Gocerelin, Buserelin, Leiprolein acetate, Tryptorelin).
Cytotoxic vashandi vekuputika
Muhosha yakaoma, cytostatics (semuenzaniso, fluorouracil) inogona kushandiswa kurapwa. Iyo nzira yekuita kwemishonga iyi inobatanidza nekwanisi yavo yekudzivisa kushandiswa kwebasa re pancreatic cells.
Migumisiro Yechechi yeCytostatics
Zvimwe zvinokonzerwa nemigumisiro mukurapa kwechitostatics ndeizvi:
- kurasikirwa kwebvudzi;
- diarrhea;
- anorexia ;
- nausea;
- kurutsa;
- headache;
- musimba simba;
- kuputsa kwekuenda kumwedzi;
- kusabereka;
- kukura kweukwepa, nekudaro.