HIV neAIDS zvirwere zvisingagoni kurapwa, asi kufambira mberi kwavo kunogona kuderedzwa kuburikidza nekugamuchirwa kwemazuva ose emishonga inokosha. Kusanganiswa kwemaretroviral therapy kunosanganisira kushandiswa kwemishonga mitatu kana ina zvichienderana nechikamu chechirwere uye muyero wakanyorwa nachiremba.
Iro antiretroviral therapy inoshanda sei?
Iyo immunodeficiency virus ine yakakura mutagenicity. Izvi zvinoreva kuti zvinopesana zvikuru nemigumisiro yakaipa yakasiyana uye inokwanisa kuchinja RNA, kuumba mitsva inoshanduka inogona kuchinja. Iyi pfuma inonyanya kuoma kurapwa kweHIV neAIDS, sezvo masero emagetsi anonyanya kukurumidza kumishonga inotorwa.
Antiretroviral therapy inobatanidza mishonga ine gumi yakasiyana-siyana, imwe neimwe yayo inokosha yekuita. Nokudaro, kutora mishonga yakawanda inopa kudzvinyirirwa kwete kwete chete rudzi rukuru rwehutachiona, asiwo chero rupi zvarwo rwakachinja mukugadzirwa kwechirwere.
Inguva ipi inonzi antiretroviral therapy inotarisirwa?
Zvinonzwisisika, kare kare kurapwa kwehutachiona hweHIV kunotanga, zviri nani kuve kumira kufambira mberi kwehutachiona, kuvandudza unhu uye tarisiro yehupenyu hwevarwere. Zvichipa kuti zviratidzo zvokutanga zvechirwere zvinowanzoenda zvisingaonekwi, antiretroviral therapy inorayirwa makore mashanu nemashanu pashure pokutapukirwa, muzviitiko zvisingawanzo nguva iyi inowedzera kusvika makore gumi.
Zvinodhaka zvehutachiona hwehutachiona hunodhaka
Mishonga inogoverwa muzvikoro:
1. Inhibitor reverse transcriptase (nucleoside):
- Videx;
- Tenofovir;
- Kivex;
- Retrovir;
- Abacavir;
- Zerit;
- Lamivudine;
- Trivizir;
- Emtriva.
2. Kwete-nucleoside reverse transcriptase inhibitors:
- Viramune;
- Stockrin;
- Delavirdine.
3. Protease inhibitors:
- Indinavir;
- Kaletra;
- Aptivus;
- Invisal;
- Ritonavir;
- Reyataz;
- Presista;
- Nelfinavir;
- Ageneraz;
- Telzir.
Inhibitors ye fusion ndeyeboka idzva remishonga yemishonga inoshanda ye antiretroviral therapy. Kusvika iye zvino chirwere chimwe chete chinonzi Fuzeon kana Enfuvirtide.
Zvakaipa zvinokonzerwa ne antiretroviral therapy
Zvisiri-zvinokuvadza zvinokanganisa:
- ruvara rweganda;
- dambudziko rekudya;
- lipodystrophy;
- hyperlipidemia;
- kurwisa insulini;
- lipoatrophy;
- pathology yepakati yenheyo system.
Dambudziko rakaipa:
- kidney stones ;
- kudzvinyirirwa kwepafupa;
- necrosis yechiropa;
- lactic acidosis;
- Fanconi syndrome;
- pancreatitis;
- hypersensitivity;
- Stevens-Johnson syndrome.