Chirwere cheAlzheimer - zvinokonzera

Panguva ino, chirwere cheAlzheimer chinokanganisa vanhu vanopfuura mamiriyoni makumi mashanu munyika yose. Muchikamu chino tichataura pamusoro pezvikonzero zvechirwere chiri mubvunzo uye nekudzivirira kwechirwere cheAlzheimer mudiki. Mukuwedzera, tinonyora zvinhu zvakawanda zvinokonzera kuwedzera kwechirwere.

Zvinokonzera Matambudziko eAlzheimer

Pasinei nehupamhi hwemishonga yemazuva ano uye nekugadzirwa kwemichina itsva, hapana kunzwisisa kwakakwana kwezvikonzero nei uropi huchibata chirwere ichi. Pane mazano matatu makuru anotsanangura kutanga kwechirwere ichi:

1. The amyloid hypothesis . Maererano neizvi shanduko yezvakakonzera kukura kwechirwere cheAlzheimer - kuiswa kwechidimbu che transmembrane protein chinonzi beta amyloid. Icho chiri chimwe chezvinhu zvakanyanya muamyloid plaques muhunhu hweuropi panguva yekuvandudzwa kwechirwere chacho. The APP gene, inotarisira mapuroteni ekugadzira ne beta-amyloid, inowanikwa pama 21 chromosomes uye inosimudzira kuunganidza amyloid kunyange muhuduku. Zvinofadza kuti chirwere chakagadzirwa makore gumi apfuura, chinogona kuparadzanisa amyloid plaques mumakumbo europi. Asi, nhamo, mushonga uyu hauna kukanganisa kudzorerwa kwekubatana kwekutya uye kushanda kweuropi.
2. Cholinergic hypothesis . Vashandi veiyi pfungwa vanoti chirwere cheAlzheimer mudiki uye chekare chinokonzerwa nekuderera kukuru mukugadzirwa kweacetylcholine, neurotransmitter inodzora kutengesa kwemasimba emagetsi kubva kumakumbo kusvika kumashuga. Pane iyi shanduro, huwandu hwakawanda hwezvirwere zveAlzheimer huchiripo, kunyange huwandu hwezvidzidzo zvakaratidza kuti kunyange mishonga yakasimba zvikuru iyo inozadza kusakwana kweacetylcholine haigoni.
3. Tau-hypothesis . Iyi nyanzvi inonyanya kukosha kusvika musi uye inosimbiswa neongororo dzakawanda. Maererano naye, mapuroteni anonzi (tau protein) anobatanidza, izvo zvinotungamirira pakuumbwa kwemakumbo eurofibrillary mukati memasero ega ega. Izvo zvakakonzerwa nemagetsi zvinokanganisa kutakura kwepakati pevhiri, zvinokanganisa microtubules uye kudzivisa kushanda kwavo.

Mukuwedzera kune zvinyorwa zvitsva pane zvinoitika zvechirwere, kunewo dzimwe nhamba dzedzimwe nzira dzisina kukodzera dzinozivikanwa. Chimwe chazvo chakavakirwa pane chirevo chokuti chirwere cheAlzheimer chakagara nhaka. Ongororo yezvokurapa inoratidza kuti iyi shanduro haina kuvhiringidzika: maitiro ekuchinja maitiro ekutanga kwechirwere chiri mubvunzo anowanikwa mune 10% chete yematambudziko.

Nzira yekudzivirira sei Alzheimer's?

Pasina kugadzirisa kwakarurama kwezvikonzero, zvakangoita kuti zvive nyore kuwedzera kurapa kwakakwana uye zvirongwa zvekudzivirira kurwara kweAlzheimer's. Kunyange zvakadaro, nyanzvi dzinokurudzira kuomerera kune utano hwakanaka, hunonzwisisika, kupa nguva yekuenzanisa kunyatsoita muviri uye kuchengetedza uropi hunoita kunyange kana ukarega.

Mukuwedzera, inozivikanwa kuti kugadzirwa kwe beta-amyloid kunogona kuderedzwa ne kudya maapuro nemajisi eapuro. Uyewo, zvimwe zvidzidzo zvemakore maviri apfuura zvakaratidza kuti njodzi yekuve nechirwere cheAlzheimer inoderedzwa nekuda kwekudya kweMediterranean , yakazara mu polyunsaturated mafuta acids, phosphorus uye mbeu yose. Vitamini D , iyo inobudiswa neganda kusangana nezuva, inodzivirirawo chiitiko chechirwere ichi.

Zvakakosha kuziva kuti kofi yakasikwa, munguva ichangopfuura isina kukodzera kubviswa kubva mukudya kwevanhu vazhinji, ine zvakanyanya kubatsira pamubongo wehuro uye inoshanda sechirwere chekudzivirira chirwere chiri mubvunzo.