Vanachiremba vakawanda vanotaura pamwe chete kuti Methotrexate mu rheumatoid arthritis ndiyo inonyanya kushandiswa yemishonga inorwisa-kupisa. Iko kunobatsira zvikuru kuwedzera kuwedzera uye kunoramba kuregererwa kwakasimba kwechirwere chacho.
Kurapa kwe methotrexate rheumatoid arthritis
Chirwere chakaonekwa munguva pfupi yapfuura, anenge makore gumi nehafu yapfuura. Ita izvi mukutambudzika kwakaoma rheumatoid arthritis. Inodzivisa kutanga nekugadzirisa kweDNA, pamwe nemasero emagetsi, izvo zvinobvumira kusimudza kupararira kwemasukisi. Icho chiri cheboka re antimetabolites, izvo zvinoratidzira. Izvo zvakanaka immunosuppressive.
Kushandiswa kwe methotrexate mu rheumatoid arthritis kwave kwakanaka kubva kumavhiki ekutanga. Mukuwedzera, inoshandiswa nyore nyore kupfuura dzimwe nzira dzokurapa. Kazhinji vanachiremba kunyange vasati vaona kuonekwa kwekupedzisira kunorayirwa ichi chirwere kuitira kuti varege kupotsa nguva uye kuti vawane hurumende yekudzikinura.
Chirongwa chokugamuchirwa nemhando yemishonga yemishonga
Methotrexate inowanikwa mumhando dzakasiyana-siyana:
- mahwendefa akavezwa (2.5, 5, 10 mg);
- mhinduro yejojo (10 mg);
- shingairira kugadzirisa kugadzirisa.
Nhamba ye methotrexate mu rheumatoid arthritis pakutanga kwekurapwa inokwana 7.5-15 mg pavhiki. Muchiitiko ichi, mishonga inonyanya kutarisirwa mumatatu matatu akaparadzaniswa, maawa gumi nemaviri. Mumwedzi mitatu, muyero uyu unowedzera kusvika 20 mg pavhiki. Izvo zvinofanira kuonekwa kuti zvakakosha kwazvo kuverenga zvakaenzana kuwanda kwemishonga kune murwere, sezvo izvi zvinogona kutungamirira kumigumisiro yakaipa yeutano, somuenzaniso, pneumonia. Sezvo murayiridzo weMethotrexate unoti, ne rheumatoid arthritis chirwere chikuru hachifaniri kudarika 25-30 mg pavhiki.
Pakupera kwemazirexate ekukurudzirwa mu rheumatoid arthritis inofanira kunyatsoderedzwa. Izvi zvinokonzerwa nekuti kuregererwa kwakasimba kwemishonga kunogona kutungamirira kune kuwedzera kwechirwere chacho. Kuderedza dhigiriro inofanira kuva inenge 2.5 mg.
Kune avo vasingakwanisi kushandisa mushonga uyu nenzira yemapiritsi nekuda kwekuonekwa kwekurutsira reflex, majekiseni anowanzotarisirwa. Izvo zvinofanira kuonekwa kuti majekesiti e methotrexate mu rheumatoid arthritis inoshanda uye inofadza. Izvi zvinokonzerwa nekuti mahwendefa anogona kukanganisa basa remuviri wepamuviri, uye zvavanoita zvinotanga mushure mechinguva. Chiyero chemhinduro yakakosha inotarirwa zvichienderana nenzvimbo yemuviri uye uremu hwayo. Kazhinji kazhinji, majekiseni anopiwa kamwe chete, uye kubva muhuwandu pane 7.5 kusvika 15 mg.
Mhedzisiro yemishonga inowanzowanzoita sevhiki yechishanu yekugamuchirwa, uye huwandu hwayo hunokwanisa kusvika shure kwegore. Sezvo mari yakawedzerwa inorayirwa anargesics chaiyo, uyewo kwete-steroidal anti-inflammatory drugs, ointments uye physiotherapy nzira.
Zvikanganiso
Kushandiswa kwe methotrexate mu rheumatoid arthritis ine urongwa hwemigumisiro yaunofanira kuigadzirira:
- nausea;
- diarrhea;
- kurutsa;
- headache;
- stomatitis ;
- maronda pamuromo mucosa;
- kusava nekubatana;
- miviri yakakura yakasimba;
- kugadzira thrombi;
- kushungurudzika kwemapfuriro ekufema.
Contraindications kutora mishonga
Methotrexate haibvumirwi nevadzimai vane pamuviri kana panguva yekurota. Usatora mushonga uyu uye vanhu vanotambura nezvirwere zvakakomba zvechiropa, itsvo uye hemopoiesis.
Methotrexate inofanira kudziviswa pamwe nemishonga inorwisa mabhakitiriya emapoka aya:
- tetracyclines ;
- sulfonamides;
- salicylates;
- barbiturates;
- cyclophosphamide;
- doxorubicin.
Uyewo, unofanirwa kurega kutora zvigadzirwa zvehupenyu, zvinogona kusanganisira iron, folic acid. Zvose izvi zvinodhaka zvinogona kuwirirana uye zvinotungamirira kutyisa muviri.