Chirwere cheAdisonison ("chirwere chendarira") chirwere chisingawanzovi chendocrine system, inotanga kurondedzerwa pakati pezana remakore rechina neChirungu-chiremba wechiremba T. Addison. Vanhu vari pakati pezera remakumi maviri nemakumi mashanu ndivo vanonyanya kutarisana nechirwere ichi. Chii chinoitika mumuviri nehutachiona ichi, chii chinokonzera kuitika kwaro uye nzira dzemazuva ano dzokurapa, tichakurukura zvakare.
Chirwere cheAdisonison - etiology uye pathogenesis
Chirwere cheAdisonison chinokonzerwa nekuparara kwepakati pemadhora eAdrenal cortex. Muchiitiko ichi, pane kuderedza kuderedza kana kupera kwakakwana kwehutachiona hwehomoni, kunyanya glucocorticoids (cortisone uye hydrocortisone) inoronga mapuroteni, makhahydrate uye mafuta metabolism, uye mineralocorticoids (deoxycorticosterone uye aldosterone) vane basa rekugadzirisa mvura-munyu metabolism.
Chikamu chechishanu chezviitiko zvechirwere ichi hazvizivikanwe zvakabva. Pamatambudziko anozivikanwa eAdisonison, tinokwanisa kusiyanisa zvinotevera:
- autoimmune lesion ye adrenal cortex;
- AIDS;
- syphilis;
- adrenoleukodystrophy;
- tuberculosis yemadonal adlands;
- amyloidosis ;
- sarcoidosis;
- kubviswa kwezvinyorwa zvinonzi adrenal;
- kuputika muzvinyorwa zvinonzi adrenal;
- kurapwa kwenguva refu nemahomoni;
- fungal lesions.
Kupera kwekugadzirwa kwemamineralocorticoids kunotungamirira kukuti muviri unorasikirwa sodium yakawandisa, yakasvibiswa, uye izwi rekupararira ropa nedzimwe zvirwere zvekurwara zvinodererawo. Kushayikwa kweglucocorticoids kunokonzera kukanganisa kwemakinhydrate metabolism, kudonha mune shuga yeropa, uye kusagadzikana kwevascular.
Zviratidzo zveDhiyabhorosi yaAdison
Sezvo mutemo, kukura kwechirwere cheAdisonison kunoitika zvishoma nezvishoma, kubva pamwedzi yakawanda kusvika kumakore akawanda, uye zviratidzo zvaro zvinowanzoenda zvisingaoneki kwenguva refu. Chirwere ichi chinogona kuitika kana muviri une chido chakanyanya che glucocorticoids, iyo inogona kusanganiswa nekushungurudzika chero kupi zvayo kana chirwere.
Zviratidzo zvechirwere zvinosanganisira:
- kuneta zvakaneta;
- musimba simba;
- zvakaderera kuyeuka;
- kurasikirwa nokurema;
- kuvhiringidzwa kwepamuviri yemimba;
- kuderera kwemuviri weropa;
- Hyperpigmentation yeganda (maruva emhangura yendarira) - inoitika nguva refu zvisati zvaonekwa kune dzimwe zviratidzo;
- Kukwezva kune zvokudya zvechikafu uye zvinovava;
- nyota;
- kusagadzikana kwezuva;
- kudengenyeka kwemaoko , musoro;
- kuwedzera kwemuti;
- tachycardia nevamwe.
Addisonian crisis
Kana zviratidzo zvechirwere zvichiitika zvisingatarisirwi nokukurumidza, kusagadzikana kwakanyanya kwerenrenocortical kunoitika. Izvi zvinonzi "addisonian crisis" uye upenyu hunopisa. Inozviratidza nezviratidzo zvakadai sokurwadziwa kunononoka kumucheto kumashure, mimba kana makumbo, kusvetuka kukuru uye kubuda, kurasikirwa kwekuziva, ruvara rwebhuruki parurimi, nezvimwewo.
Chirwere cheAdisonison - kuongororwa
Kana chirwere cheAdisonison chikafungidzirwa, kuongororwa kwe laboratori kunoitwa kuti ione kuderera kwemazinga e sodium uye mazinga e potassium, kuderera kwe serum glucose, zvakaderera zve corticosteroids muropa, kuwedzera kwehupenyu hwe eosinophils, nezvimwe.
Chirwere cheAdisonison - kurapwa
Kurapa kwechirwere kunobva pane zvinodhaka kushandiswa hormone therapy. Sezvo mutemo, kusava kwe cortisol kunotsiviwa ne hydrocortisone, uye kushayikwa kwemineral corticosteroid
Nechinetso cheAdisonison, gracocorticoids yakawanda uye yakawanda ye saline solutions ne dextrose inorayirwa, iyo inobvumira kuvandudza mamiriro ezvinhu uye kubvisa kutyisidzira kwehupenyu.
Kurapa kunosanganisira kudya kunogadzirisa kushandiswa kwenyama uye kubvisa mbatatayi yakabikwa, maruva, marimu, bhanana (kuti kuderedza kudya kwe potassium). Muitiro wekushandiswa kwemunyu, makhahydrates uye mavitamini, kunyanya C uye B, ari kuwedzera. Kufananidzira nekugadzirisa uye kwakakodzera panguva yechirwere cheAdisonison kunofadza zvikuru.