Timolol inonzi ophthalmologic antiglaucoma remedy, iri pane urongwa hwemishonga inokosha uye inokosha. Funga nezvemashoko makuru pamusoro pemadonho emeso eTimolol, ayo murwere anoda pane kushandisa mishonga iyi.
Kuumbwa uye chimiro cheTimolol kugadzirira
Sezvo mutemo, madonhwe eziso eTimolol anowanikwa mupurasitiki-droppers. Icho chinoshanda chechirwere ndeye timolol muchimiro che maleate (maleic acid salt). Iyo yakagadzikana yakagadzikana mumadonhwe eziso aya inogona kuva 0.5% (5 mg timolol mu 1 ml solution) kana 0.25% (2.5 mg timolol mu 1 ml solution).
Additives for madonhe eziso timolol:
- sodium chloride;
- benzalkonium chloride;
- sodium dihydrogen phosphate dihydrate;
- disodium phosphate dodecahydrate;
- edetate sodium;
- mvura yakasvibiswa.
Zviratidzo zvekushandiswa kwemadonho Timolol:
- ocular hypertension (kuwedzera mukati mekudzivirira mukati);
- chisinganzwisisiki - angle glaucoma ;
- Yakavharwa-angle glaucoma (pamwe chete nemaotics);
- yechipiri glaucoma (uveal, posttraumatic, aphakic);
- Congenital glaucoma (nekutadza kweimwe nzira dzokurapa).
Pharmacological action ziso madonhe Timolol
Iyo chinhu chikuru chechirwere ichi chinonyanya kushanda, kwete-selective beta-adrenergic receptor blocker (chigadziri chinononoka kubata kwemaitiro emagunha).
Izvozvo zvinokonzerwa nemishonga inonyanya kukonzerwa nekuderera kwekuvharidzirwa kwemukati wehutachiona, asi zvimwe kuwedzera mukubuda hakubviri. Matsipa eti timolol haavi nehukuru hwehukuru hwevadzidzi, pokugara uye kuvhiringidza, uyewo anobvumira kutarisa kwemukati wezvokudya (ophthalmotonus) munguva yehope.
Kuderedza ophthalmotonus kunobudirira pamwe chete nehutano hwepakutanga uye nekuwedzera kwemaitiro epakona. Mhedzisiro inoonekwa, sekutonga, maminitsi makumi maviri mushure mekushandiswa kwechirwere, inosvika pakakwirira pashure pemakore 1 kusvika ku2. Nguva yezviito zvematonsi eti timolol inenge maawa makumi maviri nemaviri.
Timolol maleate inokurumidza kupinza kuburikidza nekromaa. Muchikamu chiduku, chirwere chinopinda mumagetsi e systemic kuburikidza nekudhonza mukati memidziyo ye conjunctiva nekudhonza duct.
Method of administration and mode of dosing timolol
Maererano nemirayiridzo yekushandiswa kwemadonhwe eziso Timolol, mushonga unobviswa rimwechete kamwechete kamwe pazuva pazuva rezasi rejunjuntical yeziso rakavhiringidzika. Kuongororwa kwemugadziro kunorudzirwa nachiremba mumwe oga. Kana pane kukwana kwakakwana, iwe unofanira kuramba uchingoshandisa nzira yakawanda yakagadziriswa. Mushure mokusimudzira kuvhara kwepisocular, chirwere chemadonhwe emishonga kusvika padonho 1 kamwe pazuva.
Chirwere ichi chinotarisirwa kushandiswa kwenguva refu (pavhareji, kusvika kumavhiki matanhatu). Nguva yenguva yekurapa inoenderana nenzira yechirwere ichi. Kuputsa mumashandisi ematonsi eti timolol kana kuchinja mumushandi kunogona kuitwa chete pamusoro pekurudziro kwechiremba anoenda.
Migumisiro Yechipfuva yeTimolol Kudonha:
- kuderedza kushorwa;
- corneal anesthesia;
- pointing surface keratopathy;
- zviratidzo zvekutsamwa zvinyoro.
Mune vamwe varwere vane kushandiswa kwenguva refu kwechirwere, zvirongwa zve systemic zvinogoneka:
- arrhythmia;
- bradycardia;
- systemic hypotension;
- kupfupika kwemhepo ;
- bronchospasm;
- chizoro.
Contraindications kushandiswa kwemadonho Timolol:
- bronchial asthma;
- chronic obstructive chirwere chemapemmoni;
- sinus bradycardia;
- atrioventricular blockade ye II ne III degree;
- chirwere cheshuga mellitus;
- heart failure;
- mimba uye lactation;
- hypersensitivity kune zvikamu zvechirwere.
Timolol - zvakafanana
Timolol mukubvunzurudza nachiremba kunogona kuchinjwa nemishonga ine mishonga yakadaro yemasvomhu. Izvi zvinosanganisira:
- Asopt;
- Fotil;
- Okumed;
- Xalatan;
- Pilocarpine;
- Betoptik.