17-OH progesterone kana 17-hydroxyprogesterone inonzi steroid hormone inobudiswa muchigadzirwa che cortical ye adrenal gland uye ndiyo inotangira mahomoni akadaro se cortisol, estradiol uye testosterone. Iyo inobudiswawo mumaronda emhando dzepabonde, chibereko chakakura, yellow yellow uye placenta uye pasi pesimba re enzyme 17-20 lyase inotanga kuva mahomoni ehupombwe. Zvadaro, tichakurukura basa re-progesterone 17 riri mumuviri wevakadzi vasina kuberekwa uye pamuviri uye zviratidzo zvekuwedzera uye kusakwanira.
Zvinyorwa zvezvipenyu zvehomoni 17-oh progesterone
Nhamba yeumwe neumwe we-17-OH progesterone inodarika mukati maawa makumi maviri nemaviri. Saka, huwandu hwekufungidzirwa hunoonekwa mumangwanani emangwanani, uye zvishoma-muusiku. 17-OH progesterone muvakadzi inopesana zvichienderana nechikamu chekuenda kumwedzi. Kuwedzera kukuru kwehuwandu hwehomoni iyi kunoonekwa pausiku weivulation (kusati kwanyanya kuwedzera mu-luteinizing hormone). 17-OH progesterone muchikamu cheupenzi chinoderera nokukurumidza, chinosvika pachiyero chechikamu chekuvhura.
Iye zvino funga nezvemaitiro anozivikanwa e17-OH progesterone, zvichienderana nechikamu chekuenda kumwedzi:
- muchikamu chekutenderera - 0.99-11.51 nmol / l;
- mune follicular phase - 1,24-8,24 nmol / l;
- muchikamu chekuvhota - 0,91-4,24 nmol / l.
17-OH progesterone pakuberekwa kuwedzera, kusvika kuhuwandu hwayo mumavhiki mashoma. Munguva yepamuviri, the placenta inobvumawo kujekesa kweyi steroid hormone. Fungidzira kukosha kunobvumidzwa kwe 17-OH progesterone panguva yekuzvitakura:
- mumutatu wekutanga - 3,55-1703 nmol / l;
- muchikamu chechipiri - 3,55-20 nmol / l;
- mumutatu wechitatu - 3.75-33.33 nmol / l.
Mu premenopausal uye panguva yekupera kwemwedzi, uwandu hwehomoni 17-OH progesterone inoderera zvikuru uye inosvika 0.39-1.55 nmol / l.
Kuchinja muhutano hwe-17-OH progesterone - kuongororwa uye zviratidzo
Hauna kukwana huwandu hwe-17-OH progesterone muropa ndiyo inowanzokonzera adrenal hypoplasia uye inogona kusanganiswa nokusakwanira kugadzirwa kwemamwe mahomoni. Mune mishonga, inogona kuzviratidza nenzira yechirwere cheAdisonison, uye vakomana vanopfurikidza nekusimudzira maitiro ekunze.
Kuwedzera kwe 17-OH progesterone kunowanzoonekwa chete muhupombwe, pane dzimwe nguva inoratidza chirwere. Saka, yakakwirira 17-OH progesterone inogona kuva chiratidzo chezvipembenene zvakanyanya, mazai (maitiro anonyangadza uye polycystosis) uye zvirwere zvemajini zve adrenal cortex.
Muchipatara, kuwedzera kwe 17-OH progesterone kunogona kuratidzwa:
- kuputsa kwekuenda kumwedzi;
- kusabereka;
- kubvisa pamuviri pakarepo;
- kuberekwa kana kutangisa kufa kwevana;
- kuwedzera kweprogesterone 17-OH inogona kuratidzirwa nenyama (pimples);
- Kana 17-OH progesterone yakakwirira, testosterone inogonawo kukwidziridzwa. Izvi zvinogona kuratidzwa nenzira yekuwedzera kukura kwebvudzi pamuviri uye mumuviri (rudzi rwemvere dzembudzi).
Nhamba ye 17-OH progesterone inogona kutsanangurwa nekuongorora serum
Nokudaro, takaongorora basa rehupenyu mumuviri wehomoni 17-OH progesterone uye maitiro ayo anogamuchirwa kuvakadzi. Kupera kwemazinga ehomoni iyi kunowanzova panguva yekupera kwenguva, uye kuwedzerwa kwayo kunofanirwa kuve kwakanaka munguva dzose dzepamuviri. Kuchinja kwehuwandu hwe-17-OH progesterone mune dzimwe nguva kungave chimwe chezviratidzo zvehutachiona uye hutachiona, izvo zvinotungamirira ku hyperandrogenism, kusabereka kana kubvisa pamuviri.