Pakati pezvinodhaka zviri kuzvinzwa uye zvinokonzera kushungurudza, imwe yenzvimbo dzekutanga ndeye meldonia, chiito chiri mumuviri hachifariri kwete vanachiremba nevarwere bedzi, asiwo vatambi, varwi uye vanhuwo zvavo vasina hutano hwakakosha. Chii chinotora meldonium, chii chinoguma chizoitika mushure mokugamuchira kwayo, tichazofunga zvakare.
Meldonius - ichi chinodhaka chii?
Compound meldonium (Mildronate - zita rezvokutengeserana remishonga) rakagadzirwa mumakore makumi manomwe emakore ekupedzisira nemasayendisiti wechiLatvia Kalvinshem uye yakatanga kushandiswa mune zvekurima kukurudzira kukura kwezvipfuwo, huku uye zvirimwa. Chinhu chacho inoratidzika seanorogue yemagariro-gamma-butyrobetaine, chinyorwa che carnitine, chinhu chinobudiswa mumutambo wemabasa anokosha. Imwe yemabasa e carnitine yakabatana nemagadzirirwo emagetsi uye inosanganisira kutakura mafuta acid mu masero masero, apo mafuta anoshandurwa kuva simba.
Kubva muna 1984, meldoonia, chiito pamuviri waro chakadzidzwa kusvikira nhasi, chakatanga kushandiswa zviri pamutemo mune mushonga. Muna 2012, akabatanidzwa mune urongwa hwemishonga inokosha muRussia, uye muna 2015 World Anti-Doping Agency rakarambidza ichi chirwere chekushandisa mune zvemitambo yepamhizha (vanoongorora kune dzimwe nyika vakaona kuti meldonium inopera doping). Nhasi mishonga inowanikwa mune pharmacy mune maitiro matatu: capsules, sirasi uye sarudzo yejojo.
Meldonium - iyo nheyo yekuita
Tichaona kuti muldonium inobata sei pamatumbu emuviri. Kubva pakurongwa uku, kuva mutezo wemarma-butyrobetaine chaiwo, kunogona kukonzera kuderera kwekutengesa kwecarnitine, izvi zvinosanganisira kuderera kwekugadzirisa mafuta kune masero masero. Izvi zvinonyanya kukosha munguva yekushayikwa kweiokisijeni inowanikwa nemwoyo wemisumbu, sezvo ine kudya kazhinji kwemafuta acid uye kukwana kwema oksijeni kamwechete, kusina kukwaniswa kweiyo fatty acids kunoitika nekuunganidza kwevanhu vanovhiringidza zvinokanganisa mwoyo.
Pamwe chete nekuderera kwemasabolism e fatty acids pasi pesimba reMeldonia kuwedzera kwehuwandu hwemagetsi ehydrohydrates hunoitika, izvo zvinoda kushandiswa kwakaderera kweokisijeni. Kutenda izvi, kunyanya kuumbwa kweAATP (simba rekushandisa), kudzorera kuenzanisa pakati pekudiwa kwemasero mumhepo yeropa uye kugoverwa kwaro neropa, kunobvisa kuunganidza kwezvinokonzera tsvina mumasero.
Mukuwedzera, pamwe chete nemitambo iyi, kuwedzera kwezvakagadzirwa gamma-butyrobetaine, iyo ine vasodilating, inowanikwa. Izvi zvinosanganisira mukuzorodza musero unotapira wemidziyo yeropa, kuwedzera kubwinya kwemitsipa yeropa, kuwedzera kukwira kweropa, izvo zvinowanzotungamirirwa kunzvimbo dzeshemi.
Tinonyora zvose zvinokonzerwa nemigumisiro yekugamuchira meldonia:
- myocardioprotective;
- antihypoxic;
- angioprotective;
- anti-anginal;
- kubudirira kwekupararira kweropa;
- tonic effect;
- kuwedzera kutsungirira, simba rekushanda;
- Kudzorerwa kwechigadziro chemaoko munguva pfupi;
- kuderera muhukuru hwezviratidzo zvepfungwa nepanyama zvakanyanya;
- kushandiswa kwemasero emagetsi;
- kubviswa kwewaini kubvisa chirwere.
Chii chinoshandiswa meldonium?
Zvichipa zvinoitika pamuviri meldonium, zvinonzwisisika kuti zviishandise pamamiriro akasiyana-siyana anokonzerwa nokushayikwa kweokisijeni uye kuwedzerwa kunetseka. Kazhinji, nekuda kwechiremba, ichi chirwere hachizi chikuru chemishonga uye hachina kushandiswa zvakasiyana, asi chinorayirwa sechikamu chemishonga yakazara. Meldonia kupupurira mune zvekurapa kune zvinotevera:
- chronic heart failure;
- ischemic heart disease;
- myocardial infarction;
- angina pectoris;
- myocardial dystrophy;
- kuvhiringidzwa kwekushanda kwemwoyo yematambudziko ehutano hwehutano mukuyaruka;
- neurocirculatory dystonia muvechidiki ;
- kurohwa kweuropi;
- chisimba chisina kukwana;
- zvirwere zvemaziso zvichienderera mberi nekupararira kweropa kusina kukwana mu retina yeziso;
- kupisa mumuviri muziso reziso;
- thrombosis yepakati yemuviri kana mapazi emuziso reziso;
- retinopathy yechirwere cheshuga kana kuti yakakonzerwa nehutachiona;
- kunwa doro;
- chirwere chemapfuriro ekufema, pamwe nekushayikwa kweokisijeni (chronic bronchitis, bronchial asthma);
- kuderera kwekufunga kwepfungwa kana kwomuviri wezvakabva;
- Postoperative nguva mushure mekuvhiya kwakasiyana-siyana kwekuvhiya.
Meldonium - kushanda
Shandisa meldonium mu mahwendefa, sirasi kana mujekiseni (intravenously, intramuscularly kana parabulbar - kusangurwa kuburikidza neganda rekipiki rezasi). Nhamba, kuwanda uye nguva yekugamuchira zvakagadziriswa pane mumwe nomumwe, zvichienderana nehutano uye hutsinye hwemamiriro emurwere. Zvakakosha kunzwisisa kuti mishonga haigoni kutorwa pasina chinangwa chechiremba, nokuti kupindira kwemaitiro muitiro hunowanzoitwa nemwoyo, kukanganisa kwemasabolism yakagadzirwa nemasikirwo kunogona kuva nemigumisiro yakaipa.
Meldonium yevatambi
Kuziva kuti chii chinokonzera muldonia pamuviri, zvinova pachena kuti nei vatambi vashandisa. Icho chinoshandiswa mumhando dzose dzemitambo yemitambo: mitambo, tennis, biathlon, kurwisana, kuvaka muviri, kushambira nevamwe. Mildronate mumitambo inoshandiswa kuzadzisa zvinotevera:
- kudzivirira kuunganidzwa mumasero ezvinhu zvinokuvadza zve unacidified fatty acids;
- kuchengetedza kwemasimba metabolism mumasikirini emwoyo uye kuvandudzwa kwehupenyu hwavo;
- kuwedzera myocardial contractility;
- kunatsiridza musumbu kudya;
- kuwedzera kusimba nekubudirira kwekudzidziswa;
- kuderedza kuneta;
- kubudirira kwekuwanazve muviri shure kwekuita zvekuita.
Mavhareji ezuva nezuva emushonga wevatambi ndea 15-20 mg kilogram yehuremu mune fomu ye capsule. Inokurudzirwa kushandisa mishonga kwemaminitsi makumi matatu nemakumi mana isati yatanga basa guru. Nzira yekugamuchirwa inobva kune imwe kusvika kune mwedzi iyo, mushure mokunge iwe unofanirwa kuita nguva yekupedza mwedzi unenge. Pamberi pemakwikwi meldonium inogamuchirwa mukati memavhiki maviri, uye panguva yemakwikwi - mazuva masere anopfuura 14. Panguva ino, mushonga wacho unorambidzwa mumitambo mikuru, uye avo vanotora, avo vane ropa iro chinhu chinoonekwa, havakwanisi.
Meldonias in Diabetes
Munguva pfupi yapfuura, mildonia yakashandiswa kurudzi rwechipiri uye chirwere cheshuga chirwere cheshuga, zvichibva pane zvidzidzo zvakaratidza kubvira kwechimwe chinhu kuderedza kusanganiswa kweglucose muropa. Panguva imwecheteyo, kukohwa kwe insulini hakuiti. Kakawanda nechirwere ichi, mushonga unorayirwa pamwe nekushandiswa panguva imwe chete ye metformin (mutengesi-kuderedza shuga kubva mukirasi guru). Kurapa kwakadaro, kuwedzera pakuderedza shuga yeropa, kunopa zvinotevera:
- kudzivirirwa kwekusagadzikana kwekusagadzikana uye kurasikirwa kwekunzwisisika kunorwadziwa;
- rubatsiro rwemutsipa wemwoyo, kudzorerwa kwemagetsi matsvina mukati maro;
- kudzivirira kubatanidzwa kwechirwere cheshuga asidi, neuropathy uye kuneta;
- kudzivirira kwezvipembenene zvekudzorera.
Meldonias ane arrhythmia yemwoyo
Kana mwoyo wemasumbu inoshanda zvisina kururama, iyo yakagadzikana mwoyo rhythm inoputsika - an arrhythmia. Munyaya iyi, nyanzvi dzinogona kukurudzira meldonium, kushandiswa kwemishonga inoratidzira migumisiro yakanaka. Paunenge uchishandisa mushonga uyu mukurapa kwakaoma, zvinoita kuti uwane kugadzikana kusimbiswa kwehutano hwekushaya mwoyo. Pamusana pokutora mishonga kune varwere, njodzi yekudzidzira angina pectoris , myocardial infarction yakaderera.
Meldonium kubva pakamanikidzwa
Meldonium, iyo ine simba pamuviri unozviratidza zvakanyanya maererano nekushanda kwemwoyo yemagetsi, ichave yakakosha kune varwere vane ropa rakanyanya. Zvidzidzo zvinoratidza kuti mishonga iyi, pamwe chete nemigumisiro yepamusoro yekurapa (pakati peiyo inokosha kukosha kwevasodilating yekuderedza kushandiswa), inobatsira kuderedza kuwedzera kwezinga reku cholesterol muropa - chikonzero chinowanzokonzera huwandu hwehutano. Muchiitiko ichi, varwere vanogona kukurudzirwa kushandisa meldonium intramuscularly.
Meldonium ine doro
Kubudirira meldonia kubva kune hangover , kuratidzirwa kwekuregera zviratidzo kune varwere vane doro risingagumi. Iyo mishonga haisi kungovandudza hukama hwakanaka, asi inodzivirira kutanga kwemigumisiro yakaipisisa inobatanidza nemigumisiro yekudhakwa pamwoyo nepfungwa. Ivhareji yevhesi imwe chete munyaya iyi i 500 mg, iyo inotora 3-4 mara pazuva kwemazuva 7-10. Zvidzidzo zvekurapa zvinoshandiswa panguva dzenguva miviri.
Meldoniy kubva kuneta
Mune zvimwe zviitiko, mishonga meldoniy yakasarudzwa kuti ishaire kusingaperi inobatanidza kuwedzera mupfungwa uye mupfungwa kunetseka, uye kana muviri wakaneta nemhaka yechirwere chenguva refu. Iyo mishonga, iyo inobatsira chaizvo, inobatsira muviri kuti utsungirire kushungurudzika kusina kukanganisa kuhutano hwemwoyo, pane kupora, kubvisa kusava nesimba uye kurara.
Meldonium - madhara
Ngatitsanangurirei mimwe migumisiro meldoniy inokwanisa kukanganisa:
- kunyanya kukonzera, kuparara kwehope;
- headache;
- chizoro;
- ruzha munzeve;
- kudengenyeka;
- kuora mwoyo kwekunzwa;
- pfungwa yekutya;
- kuchinja muropa;
- tachycardia;
- kushungurudzika mumoyo;
- pallor kana hypermia;
- dyspepsia;
- chifuva;
- tsvina yesimbi mumuromo;
- akaoma muromo;
- kurwadziwa kwepamuviri;
- diarrhea;
- misuli spasms;
- kuzvimba;
- zvinokonzerwa nezvinokonzerwa nemararamiro (rash, itching, quincke's edema) nevamwe.
Ko mharira inoshandiswa nayo here?
Yakawanikwa kuti meldonium uye Mildronate, nekushandiswa kwenguva refu, vanodhakwa mune vamwe vanhu. Kunyanya kuoneka kuipa kwevatambi avo, mushure mekurega kushandiswa kwemishonga, vanotanga kuve nezvinetso zvepfungwa - kunzwa kwekusagadzirira kudzidzira kana kukwikwidzana, kuneta kwakakurumidza, kushaya simba.
Meldonium - contraindications yekushandiswa
Mishonga yekugadzirira meldonium zvinopesana nezvisarudzo zvinotevera:
- kunzwisiswa kwega kwezvinhu zvechirwere ichi;
- kuwedzera kusagadzikana kwechisimba;
- renal or hepatic insufficiency, severe;
- pamuviri, nguva yekuyamwisa.
Meldonium - zvakafanana zvekugadzirira
Kana zvisiri kukwanisika kutora zvinodhaka zvine meldonium, zvakafanana kuratidzira mamiriro ehutachiona akadaro zvinogona kushandiswa mukubvumirana nachiremba. Mishonga yakadaro inosanganisira:
- Dibikor;
- Vero-Riboxin;
- Berlition;
- Coenzyme Q10;
- Lipamid;
- Riboxin .